Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod
Fredrik Piehl, Ingrid Kockum, Mohsen Khademi, Kaj Blennow, Jan Lycke, Henrik Zetterberg, Tomas Olsson
Multiple Sclerosis Journal - Peer reviewed - Access status: Green - DOI: 10.1177/1352458517715132 -
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
Sigurgeir Olafsson, Pernilla Stridh, Steffan Daniël Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J. Geirsson, Arni V. Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G. Jonasson, Jon Hjaltalin Olafsson, Kjartan B. Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Thorarinn Gislason, Trausti Valdimarsson, Evgenia Mikaelsdottir, Snaevar Sigurdsson, Stefan Jonsson, Thorunn Rafnar, Dag Aarsland, Srdjan Djurovic, Tormod Fladby, Gun Peggy Knudsen, Elisabeth G. Celius, Kjell-Morten Myhr, Gerdur Grondal, Kristjan Steinsson, Helgi Valdimarsson, Sigurdur Bjornsson, Unnur S. Bjornsdottir, Einar S Bjornsson, Bjorn Nilsson, Ole A. Andreassen, Lars Alfredsson, Jan Hillert, Ingrid Skelton Kockum, Gisli Masson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hreinn Stefansson, Haukur Hjaltason, Hanne F. Harbo, Tomas Olsson, Ingileif Jonsdottir, Kari Stefansson
npj Genomic Medicine - Peer reviewed - Access status: Gold - DOI: 10.1038/s41525-017-0027-2 - Read more...
Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients
Tojo James, Magdalena Lindén, Hiromasa Morikawa, Sunjay Jude Fernandes, Sabrina Ruhrmann, Mikael Huss, Maya Brandi, Fredrik Piehl, Maja Jagodic, Jesper Tegnér, Mohsen Khademi, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum
Human Molecular Genetics - Peer reviewed - Access status: Gold - DOI: 10.1093/hmg/ddy001 -
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
Lara Kular, Yun Liu, Sabrina Ruhrmann, Galina Zheleznyakova, Francesco Marabita, David Gomez-Cabrero, Tojo James, Ewoud Ewing, Magdalena Lindén, Bartosz Górnikiewicz, Shahin Aeinehband, Pernilla Stridh, Jenny Link, Till F. M. Andlauer, Christiane Gasperi, Heinz Wiendl, Frauke Zipp, Ralf Gold, Björn Tackenberg, Frank Weber, Bernhard Hemmer, Konstantin Strauch, Stefanie Heilmann-Heimbach, Rajesh Rawal, Ulf Schminke, Carsten O. Schmidt, Tim Kacprowski, Andre Franke, Matthias Laudes, Alexander T. Dilthey, Elisabeth G. Celius, Helle B. Søndergaard, Jesper Tegnér, Hanne F. Harbo, Annette B. Oturai, Sigurgeir Olafsson, Hannes P. Eggertsson, Bjarni V. Halldorsson, Haukur Hjaltason, Elias Olafsson, Ingileif Jonsdottir, Kari Stefansson, Tomas Olsson, Fredrik Piehl, Tomas J. Ekström, Ingrid Kockum, Andrew P. Feinberg, Maja Jagodic
Nature Communications - Peer reviewed - Access status: Gold - DOI: 10.1038/s41467-018-04732-5 - Read more...
Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis
Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Multiple Sclerosis Journal - Experimental, Translational and Clinical - Peer reviewed - Access status: Gold - DOI: 10.1177/2055217318767192 - Read more...
Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity
Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck, Dirk S. Paul
BioEssays - Peer reviewed - Access status: Gold - DOI: 10.1002/bies.201700148 - Read more...
Epigenetic variation taking center stage in immunological research
Simone Ecker, Stephan Beck
Epigenomics - Peer reviewed - Access status: Gold - DOI: 10.2217/epi-2017-0006 - Read more...
Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins
Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
Genome Medicine - Peer reviewed - Access status: Green - DOI: 10.1186/s13073-018-0575-9 - Read more...
Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells
Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, Bénédicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer
Brain - Peer reviewed - Access status: Gold - DOI: 10.1093/brain/awx372 - Read more...
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
Francesco Marabita, Malin Almgren, Louise K. Sjöholm, Lara Kular, Yun Liu, Tojo James, Nimrod B. Kiss, Andrew P. Feinberg, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Tomas J. Ekström, Maja Jagodic
Scientific Reports - Peer reviewed - Access status: Gold - DOI: 10.1038/s41598-017-14788-w - Read more...
Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes
Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, Lara Kular, Julio Cesar Cetrulo Lorenzi, Sunjay Jude Fernandes, Hiromasa Morikawa, Shahin Aeinehband, Sergi Sayols-Baixeras, Stella Aslibekyan, Devin M Absher, Donna K Arnett, Jesper Tegner, David Gomez-Cabrero, Fredrik Piehl, Maja Jagodic
Multiple Sclerosis Journal - Peer reviewed - Access status: Gold - DOI: 10.1177/1352458517721356 - Read more...
Ensembl 2018
Daniel R Zerbino, Premanand Achuthan, Wasiu Akanni, M Ridwan Amode, Daniel Barrell, Jyothish Bhai, Konstantinos Billis, Carla Cummins, Astrid Gall, Carlos García Girón, Laurent Gil, Leo Gordon, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Jimmy Kiang To, Matthew R Laird, Ilias Lavidas, Zhicheng Liu, Jane E Loveland, Thomas Maurel, William McLaren, Benjamin Moore, Jonathan Mudge, Daniel N Murphy, Victoria Newman, Michael Nuhn, Denye Ogeh, Chuang Kee Ong, Anne Parker, Mateus Patricio, Harpreet Singh Riat, Helen Schuilenburg, Dan Sheppard, Helen Sparrow, Kieron Taylor, Anja Thormann, Alessandro Vullo, Brandon Walts, Amonida Zadissa, Adam Frankish, Sarah E Hunt, Myrto Kostadima, Nicholas Langridge, Fergal J Martin, Matthieu Muffato, Emily Perry, Magali Ruffier, Dan M Staines, Stephen J Trevanion, Bronwen L Aken, Fiona Cunningham, Andrew Yates, Paul Flicek
Nucleic Acids Research - Peer reviewed - Access status: Gold - DOI: 10.1093/nar/gkx1098 - Read more...
Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk
Katarina Tengvall, Jesse Huang, Cecilia Hellström, Patrick Kammer, Martin Biström, Burcu Ayoglu, Izaura Lima Bomfim, Pernilla Stridh, Julia Butt, Nicole Brenner, Angelika Michel, Karin Lundberg, Leonid Padyukov, Ingrid E. Lundberg, Elisabet Svenungsson, Ingemar Ernberg, Sigurgeir Olafsson, Alexander T. Dilthey, Jan Hillert, Lars Alfredsson, Peter Sundström, Peter Nilsson, Tim Waterboer, Tomas Olsson, Ingrid Kockum
Proceedings of the National Academy of Sciences - Peer reviewed - Access status: Gold - DOI: doi: 10.1073/pnas.1902623116 - Read more...
Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients
Sunjay Jude Fernandes, Hiromasa Morikawa, Ewoud Ewing, Sabrina Ruhrmann, Rubin Narayan Joshi, Vincenzo Lagani, Nestoras Karathanasis, Mohsen Khademi, Nuria Planell, Angelika Schmidt, Ioannis Tsamardinos, Tomas Olsson, Fredrik Piehl, Ingrid Kockum, Maja Jagodic, Jesper Tegnér, David Gomez-Cabrero
Scientific Reports - Peer reviewed - Access status: Gold - DOI: doi: 10.1038/s41598-019-48493-7 -
The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status
Anna Karin Hedström, Ola Hössjer, Jan Hillert, Pernilla Stridh, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Multiple Sclerosis Journal - Peer reviewed - Access status: Green - DOI: doi: 10.1177/1352458519877685 - Read more...
Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis
Elin Engdahl, Rasmus Gustafsson, Jesse Huang, Martin Biström, Izaura Lima Bomfim, Pernilla Stridh, Mohsen Khademi, Nicole Brenner, Julia Butt, Angelika Michel, Daniel Jons, Maria Hortlund, Lucia Alonso-Magdalena, Anna Karin Hedström, Louis Flamand, Masaru Ihira, Tetsushi Yoshikawa, Oluf Andersen, Jan Hillert, Lars Alfredsson, Tim Waterboer, Peter Sundström, Tomas Olsson, Ingrid Kockum, Anna Fogdell-Hahn
Frontiers in Immunology - Peer reviewed - Access status: Gold - DOI: doi: 10.3389/fimmu.2019.02715 - Read more...
Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
Ali Manouchehrinia, Fredrik Piehl, Jan Hillert, Jens Kuhle, Lars Alfredsson, Tomas Olsson, Ingrid Kockum
Annals of Clinical and Translational Neurology - Peer reviewed - Access status: Gold - DOI: doi: 10.1002/acn3.50972 -
Low sun exposure increases multiple sclerosis risk both directly and indirectly
Anna Karin Hedström, Tomas Olsson, Ingrid Kockum, Jan Hillert, Lars Alfredsson
Journal of Neurology - Peer reviewed - Access status: Gold - DOI: doi: 10.1007/s00415-019-09677-3 -
Blood neurofilament light levels segregate treatment effects in multiple sclerosis
Bénédicte Delcoigne, Ali Manouchehrinia, Christian Barro, Pascal Benkert, Zuzanna Michalak, Ludwig Kappos, David Leppert, Jon A. Tsai, Tatiana Plavina, Bernd C. Kieseier, Jan Lycke, Lars Alfredsson, Ingrid Kockum, Jens Kuhle, Tomas Olsson, Fredrik Piehl
Neurology - Peer reviewed - Access status: Gold - DOI: doi: 10.1212/wnl.0000000000009097 -
Validation of rapid magnetic resonance myelin imaging in multiple sclerosis
Russell Ouellette, Gabriel Mangeat, Ildiko Polyak, Marcel Warntjes, Yngve Forslin, åsa Bergendal, Michael Plattén, Martin Uppman, Constantina Andrada Treaba, Julien Cohen‐Adad, Fredrik Piehl, Maria Kristoffersen Wiberg, Sten Fredrikson, Caterina Mainero, Tobias Granberg
Annals of Neurology - Peer reviewed - Access status: Gold - DOI: doi: 10.1002/ana.25705 -
Towards a European health research and innovation cloud (HRIC)
F. M. Aarestrup, A. Albeyatti, W. J. Armitage, C. Auffray, L. Augello, R. Balling, N. Benhabiles, G. Bertolini, J. G. Bjaalie, M. Black, N. Blomberg, P. Bogaert, M. Bubak, B. Claerhout, L. Clarke, B. De Meulder, G. D’Errico, A. Di Meglio, N. Forgo, C. Gans-Combe, A. E. Gray, I. Gut, A. Gyllenberg, G. Hemmrich-Stanisak, L. Hjorth, Y. Ioannidis, S. Jarmalaite, A. Kel, F. Kherif, J. O. Korbel, C. Larue, M. Laszlo, A. Maas, L. Magalhaes, I. Manneh-Vangramberen, E. Morley-Fletcher, C. Ohmann, P. Oksvold, N. P. Oxtoby, I. Perseil, V. Pezoulas, O. Riess, H. Riper, J. Roca, P. Rosenstiel, P. Sabatier, F. Sanz, M. Tayeb, G. Thomassen, J. Van Bussel, M. Van den Bulcke, H. Van Oyen
Genome Medicine - Peer reviewed - Access status: Gold - DOI: doi: 10.1186/s13073-020-0713-z -
CHIT1 at Diagnosis Reflects Long‐Term Multiple Sclerosis Disease Activity
Emanuela Oldoni, Ide Smets, Klara Mallants, Marijne Vandebergh, Lies Van Horebeek, Koen Poesen, Patrick Dupont, Bénédicte Dubois, An Goris
Annals of Neurology - Peer reviewed - Access status: Gold - DOI: doi: 10.1002/ana.25691 -
Somatic Variants: New Kids on the Block in Human Immunogenetics
L. Van Horebeek, B. Dubois, A. Goris
Trends in Genetics - Peer reviewed - Access status: Gold - DOI: doi: 10.1016/j.tig.2019.09.005 -
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Patsopoulos, N.A., Baranzini, S.E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A.H., James, T., Replogle, J., Vlachos, I.S., McCabe, C., Pers, T.H., Brandes, A., White, C., Keenan, B., Cimpean, M., Winn, P., Panteliadis, I-P., Robbins, A., Andlauer, T.F M., Zarzycki, O., Dubois, B., Goris, A., Sondergaard, H.B., Sellebjerg, F., Sorensen, P.S., Ullum, H., Thorner, L.W., Saarela, J., Cournu-Rebeix, I., Damotte, V., Fontaine, B., Guillot-Noel, L., Lathrop, M., Vukusic, S., Berthele, A., Pongratz, V., Pongratz, V., Gasperi, C., Graetz, C., Grummel, V., Hemmer, B., Hoshi, M., Knier, B., Korn, T., Lill, C.M., Luessi, F., Muehlau, M., Zipp, F., Dardiotis, E., Agliardi, C., Amoroso, A., Barizzone, N., Benedetti, M.D., Bernardinelli, L., Cavalla, P., Clarelli, F., Comi, G., Cusi, D., Esposito, F., Ferre, L., Galimberti, D., Guaschino, C., Leone, M.A., Martinelli, V., Moiola, L., Salvetti, M., Sorosina, M., Vecchio, D., Zauli, A., Santoro, S., Mancini, N., Zuccala, M., Mescheriakova, J., van Duijn, C., Bos, S.D., Celius, E.G., Spurkland, A., Comabella, M., Montalban, X., Alfredsson, L., Bomfim, I.L., Gomez-Cabrero, D., Hillert, J., Jagodic, M., Linden, M., Piehl, F., Jelcic, I., Martin, R., Sospedra, M., Baker, A., Ban, M., Hawkins, C., Hysi, P., Kalra, S., Karpe, F., Khadake, J., Lachance, G., Molyneux, P., Neville, M., Thorpe, J., Bradshaw, E., Caillier, S.J., Calabresi, P., Cree, B.A C., Cross, A., Davis, M., de Bakker, P.W I., Delgado, S., Dembele, M., Edwards, K., Fitzgerald, K., Frohlich, I.Y., Gourraud, P-A., Haines, J.L., Hakonarson, H., Kimbrough, D., Isobe, N., Konidari, I., Lathi, E., Lee, M.H., Li, T., An, D., Zimmer, A., Madireddy, L., Manrique, C.P., Mitrovic, M., Olah, M., Patrick, E., Pericak-Vance, M.A., Piccio, L., Schaefer, C., Weiner, H., Lage, K., Scott, R.J., Lechner-Scott, J., Leal, R., Moscato, P., Booth, D.R., Stewart, G.J., Vucic, S., Pame, G., BamettO, M., Mason, D., GriffithS, L., Broadley, S., Tajouri, L., Baxter, A., Slee, M., Taylor, B.V., Charlesworth, J., Kilpatrick, T.J., Rubio, J., Jokubaitis, V., Wiley, J., Butzkueven, H., Leslie, S., Motyer, A., Stankovich, J., Carroll, W.M., Kermode, A.G., Edrin, M., Barclay, M., Peyrin-Biroulet, L., Chamaillard, M., Colombe, J-F., Cottone, M., Croft, A., D'Inca, R., Halfvarson, J., Hanigan, K., Henderson, P., Hugot, J-P., Karban, A., Kennedy, N.A., Khan, M.A., Lemann, M., Levine, A., Massey, D., Milla, M., Motoey, G.W., Ng, S.M E., Oikonomnou, J., Peeters, H., Proctor, D.D., Rahier, J-F., Roberts, R., Rutgeerts, P., Seibold, F., Stronati, L., Taylor, K.M., Torkvist, L., Ublick, K., Van Limbergen, J., Van Gossum, A., Vatn, M.H., Zhang, H., Zhang, W., Donnelly, P., Barroso, I., Blackwe, J.M., Bramon, E., Brown, M.A., Casas, J.P., Corvin, A., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H.S., Mathew, C.G., Palmer, C.N A., Plomin, R., Rautanen, A., Sawcer, S.J., Trembath, R.C., Viswanathan, A.C., Wood, N.W., Spencer, C.C A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R., Strange, A., Sul, Z., Vukcevic, D.A., Donnelly, P., Langford, C., Hunt, S.E., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, S.J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O.T., Liddle, J., Potter, S.C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Barroso, I., Deloukas, P., Mathew, C.G., Blackwe, J.M., Brown, M.A., Corvin, A., Spencer, C.C A., Compston, A., Hafler, D., Harbo, H.F., Hauser, S.L., Stewart, G., D'Alfonso, S., Hadjigeorgiou, G., Taylor, B., Barcellos, L.F., Booth, D., Hintzen, R., Kockum, I., Martinelli-Boneschi, F., McCauley, J.L., Oksenberg, J.R., Oturai, A., Sawcer, S., Ivinson, A.J., Olsson, T., De Jager, P.L.
Science - Peer reviewed - Access status: No - DOI: doi: 10.1126/science.aav7188 -
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis
Madireddy, L., Patsopoulos, N.A., Cotsapas, C., Bos, S.D., Beecham, A., McCauley, J., Kim, K., Jia, X., Santaniello, A., Caillier, S.J., Andlauer, T.F M., Barcellos, L.F., Berge, T., Bernardinelli, L., Martinelli-Boneschi, F., Booth, D.R., Briggs, F., Celius, E.G., Comabella, M., Comi, G., Cree, B.A C., D'Alfonso, S., Dedham, K., Duquette, P., Efthimios, D., Esposito, F., Fontaine, B., Gasperi, C., Goris, A., Dubois, B., Gourraud, P-A., Hadjigeorgiou, G., Haines, J., Hawkins, C., Hemmer, B., Hintzen, R., Horakova, D., Isobe, N., Kalra, S., Kira, J-I., Khalil, M., Kockum, I., Lill, C.M., Lincoln, M.R., Luessi, F., Martin, R., Oturai, A., Palotie, A., Pericak-Vance, M.A., Henry, R., Saarela, J., Ivinson, A., Olsson, T., Taylor, B.V., Stewart, G.J., Harbo, H.F., Compston, A., Hauser, S.L., Hafler, D.A., Zipp, F., De Jager, P., Sawcer, S., Oksenberg, J.R., Baranzini, S.E.
Nature Communications - Peer reviewed - Access status: Gold - DOI: doi: 10.1038/s41467-019-09773-y -
Leveraging human genetics to inform intervention strategies for multiple sclerosis
An Goris, Bénédicte Dubois
Neurology - Peer reviewed - Access status: No - DOI: doi: 10.1212/wnl.0000000000007298 -
A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease
Lies Van Horebeek, Kelly Hilven, Klara Mallants, Annemarie Van Nieuwenhuijze, Tiina Kelkka, Paula Savola, Satu Mustjoki, Susan M Schlenner, Adrian Liston, Bénédicte Dubois, An Goris
Human Molecular Genetics - Peer reviewed - Access status: Gold - DOI: doi: 10.1093/hmg/ddy425 -
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk
Mitja Mitrovič, Nikolaos A. Patsopoulos, Ashley H. Beecham, Theresa Dankowski, An Goris, Bénédicte Dubois, Marie B. D’hooghe, Robin Lemmens, Philip Van Damme, Helle Bach Søndergaard, Finn Sellebjerg, Per Soelberg Sorensen, Henrik Ullum, Lise W. Thørner, Thomas Werge, Janna Saarela, Isabelle Cournu-Rebeix, Vincent Damotte, Bertrand Fontaine, Lena Guillot-Noel, Mark Lathrop, Sandra Vukusik, Pierre-Antoine Gourraud, Till F.M. Andlauer, Viola Pongratz, Dorothea Buck, Christiane Gasperi, Antonios Bayas, Christoph Heesen, Tania Kümpfel, Ralf Linker, Friedemann Paul, Martin Stangel, Björn Tackenberg, Florian Then Bergh, Clemens Warnke, Heinz Wiendl, Brigitte Wildemann, Uwe Zettl, Ulf Ziemann, Hayrettin Tumani, Ralf Gold, Verena Grummel, Bernhard Hemmer, Benjamin Knier, Christina M. Lill, Felix Luessi, Efthimios Dardiotis, Cristina Agliardi, Nadia Barizzone, Elisabetta Mascia, Luisa Bernardinelli, Giancarlo Comi, Daniele Cusi, Federica Esposito, Laura Ferrè, Cristoforo Comi, Daniela Galimberti, Maurizio A. Leone, Melissa Sorosina, Julia Mescheriakova, Rogier Hintzen, Cornelia van Duijn, Charlotte E. Teunissen, Steffan D. Bos, Kjell-Morten Myhr, Elisabeth G. Celius, Benedicte A. Lie, Anne Spurkland, Manuel Comabella, Xavier Montalban, Lars Alfredsson, Pernilla Stridh, Jan Hillert, Maja Jagodic, Fredrik Piehl, Ilijas Jelčić, Roland Martin, Mireia Sospedra, Maria Ban, Clive Hawkins, Pirro Hysi, Seema Kalra, Fredrik Karpe, Jyoti Khadake, Genevieve Lachance, Matthew Neville, Adam Santaniello, Stacy J. Caillier, Peter A. Calabresi, Bruce A.C. Cree, Anne Cross, Mary F. Davis, Jonathan L. Haines, Paul I.W. de Bakker, Silvia Delgado, Marieme Dembele, Keith Edwards, Kathryn C. Fitzgerald, Hakon Hakonarson, Ioanna Konidari, Ellen Lathi, Clara P. Manrique, Margaret A. Pericak-Vance, Laura Piccio, Cathy Schaefer, Cristin McCabe, Howard Weiner, Jacqueline Goldstein, Tomas Olsson, Georgios Hadjigeorgiou, Bruce Taylor, Lotti Tajouri, Jac Charlesworth, David R. Booth, Hanne F. Harbo, Adrian J. Ivinson, Stephen L. Hauser, Alastair Compston, Graeme Stewart, Frauke Zipp, Lisa F. Barcellos, Sergio E. Baranzini, Filippo Martinelli-Boneschi, Sandra D’Alfonso, Andreas Ziegler, Annette Oturai, Jacob L. McCauley, Stephen J. Sawcer, Jorge R. Oksenberg, Philip L. De Jager, Ingrid Kockum, David A. Hafler, Chris Cotsapas
Cell - Peer reviewed - Access status: Gold - DOI: doi: 10.1016/j.cell.2018.09.049 -
LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients
Chiara Fenoglio, Emanuela Oldoni, Maria Serpente, Milena A. De Riz, Marina Arcaro, Marianna D'Anca, Anna M. Pietroboni, Alberto Calvi, Elisabetta Lecchi, An Goris, Klara Mallants, Bénédicte Dubois, Cristoforo Comi, Roberto Cantello, Elio Scarpini, Daniela Galimberti
Journal of Neuroimmunology - Peer reviewed - Access status: No - DOI: doi: 10.1016/j.jneuroim.2018.08.008 -
Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators
Vasiliki Lagou, Josselyn E. Garcia-Perez, Ide Smets, Lies Van Horebeek, Marijne Vandebergh, Liye Chen, Klara Mallants, Teresa Prezzemolo, Kelly Hilven, Stephanie Humblet-Baron, Matthieu Moisse, Philip Van Damme, Guy Boeckxstaens, Paul Bowness, Bénédicte Dubois, James Dooley, Adrian Liston, An Goris
Cell Reports - Peer reviewed - Access status: Gold - DOI: doi: 10.1016/j.celrep.2018.09.048 -
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning
Janine Arloth, Gökcen Eraslan, Till F. M. Andlauer, Jade Martins, Stella Iurato, Brigitte Kühnel, Melanie Waldenberger, Josef Frank, Ralf Gold, Bernhard Hemmer, Felix Luessi, Sandra Nischwitz, Friedemann Paul, Heinz Wiendl, Christian Gieger, Stefanie Heilmann-Heimbach, Tim Kacprowski, Matthias Laudes, Thomas Meitinger, Annette Peters, Rajesh Rawal, Konstantin Strauch, Susanne Lucae, Bertram Müller-Myhsok, Marcella Rietschel, Fabian J. Theis, Elisabeth B. Binder, Nikola S. Mueller
PLOS Computational Biology - Peer reviewed - Access status: Gold - DOI: doi: 10.1371/journal.pcbi.1007616 -
Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases
Gildas Lepennetier, Zsuzsanna Hracsko, Marina Unger, Martijn Van Griensven, Verena Grummel, Markus Krumbholz, Achim Berthele, Bernhard Hemmer, Markus C. Kowarik
Journal of Neuroinflammation - Peer reviewed - Access status: Gold - DOI: 10.1186/s12974-019-1601-6 -
Prognostic value of white matter lesion shrinking in early multiple sclerosis: An intuitive or naïve notion?
Viola Pongratz, Paul Schmidt, Matthias Bussas, Sophia Grahl, Christian Gaser, Achim Berthele, Muna‐Miriam Hoshi, Jan Kirschke, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
Brain and Behavior - Peer reviewed - Access status: Gold - DOI: doi: 10.1002/brb3.1417 -
A large case-control study on vaccination as risk factor for multiple sclerosis
Alexander Hapfelmeier, Christiane Gasperi, Ewan Donnachie, Bernhard Hemmer
Neurology - Peer reviewed - Access status: No - DOI: doi: 10.1212/wnl.0000000000008012 -
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
Sven J. van der Lee, Olivia J. Conway, Iris Jansen, Minerva M. Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R. van Eijk, Najada Stringa, Jason A. Chen, Anna Zettergren, Till F. M. Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E. Savage, Jonas Mengel-From, Sonia Moreno-Grau, Michael Wagner, Juan Fortea, Michael J. Keogh, Kaj Blennow, Ingmar Skoog, Manuel A. Friese, Olga Pletnikova, Miren Zulaica, Carmen Lage, Itziar de Rojas, Steffi Riedel-Heller, Ignacio Illán-Gala, Wei Wei, Bernard Jeune, Adelina Orellana, Florian Then Bergh, Xue Wang, Marc Hulsman, Nina Beker, Niccolo Tesi, Christopher M. Morris, Begoña Indakoetxea, Lyduine E. Collij, Martin Scherer, Estrella Morenas-Rodríguez, James W. Ironside, Bart N. M. van Berckel, Daniel Alcolea, Heinz Wiendl, Samantha L. Strickland, Pau Pastor, Eloy Rodríguez Rodríguez, Bradley F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Jay A. van Gerpen, Marcel J. T. Reinders, Ryan J. Uitti, Lluís Tárraga, Wolfgang Maier, Oriol Dols-Icardo, Amit Kawalia, Maria Carolina Dalmasso, Mercè Boada, Uwe K. Zettl, Natasja M. van Schoor, Marian Beekman, Mariet Allen, Eliezer Masliah, Adolfo López de Munain, Alexander Pantelyat, Zbigniew K. Wszolek, Owen A. Ross, Dennis W. Dickson, Neill R. Graff-Radford, David Knopman, Rosa Rademakers, Afina W. Lemstra, Yolande A. L. Pijnenburg, Philip Scheltens, Thomas Gasser, Patrick F Chinnery, Bernhard Hemmer, Martijn A. Huisman, Juan Troncoso, Fermin Moreno, Ellen A. Nohr, Thorkild I. A. Sørensen, Peter Heutink, Pascual Sánchez-Juan, Danielle Posthuma, Jordi Clarimón, Kaare Christensen, Nilüfer Ertekin-Taner, Sonja W. Scholz, Alfredo Ramirez, Agustín Ruiz, Eline Slagboom, Wiesje M. van der Flier, Henne Holstege
Acta Neuropathologica - Peer reviewed - Access status: Gold - DOI: doi: 10.1007/s00401-019-02026-8 -
A Systematic Assessment of Prevalence, Incidence and Regional Distribution of Multiple Sclerosis in Bavaria From 2006 to 2015
Tanja Daltrozzo, Alexander Hapfelmeier, Ewan Donnachie, Antonius Schneider, Bernhard Hemmer
Frontiers in Neurology - Peer reviewed - Access status: Gold - DOI: doi: 10.3389/fneur.2018.00871 -
CSF parameters associated with early MRI activity in patients with MS
Ana Klein, Rebecca C. Selter, Alexander Hapfelmeier, Achim Berthele, Bertram Müller-Myhsok, Viola Pongratz, Christiane Gasperi, Claus Zimmer, Mark Mühlau, Bernhard Hemmer
Neurology - Neuroimmunology Neuroinflammation - Peer reviewed - Access status: Gold - DOI: doi: 10.1212/nxi.0000000000000573 -
Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis
Christiane Gasperi, Anke Salmen, Gisela Antony, Antonios Bayas, Christoph Heesen, Tania Kümpfel, Ralf A. Linker, Friedemann Paul, Martin Stangel, Björn Tackenberg, Florian Then Bergh, Clemens Warnke, Frank Weber, Heinz Wiendl, Brigitte Wildemann, Uwe K. Zettl, Ulf Ziemann, Frauke Zipp, Hayrettin Tumani, Ralf Gold, Bernhard Hemmer
JAMA Neurology - Peer reviewed - Access status: Gold - DOI: doi: 10.1001/jamaneurol.2019.0905 -
Impact of multiple sclerosis risk loci in postinfectious neurological syndromes
Filippo Martinelli-Boneschi, Riccardo Currò, Silvia Santoro, Giulia Berzero, Melissa Sorosina, Laura Ferrè, Elisabetta Mascia, Silvia Peroni, Giancarlo Comi, Angelo Gugliemi, Elisa Vegezzi, Ilaria Callegari, Massimo Filippi, Andrea Cortese, Federica Esposito, Ferdinando Clarelli, Enrico Marchioni
Multiple Sclerosis and Related Disorders - Peer reviewed - Access status: No - DOI: 10.1016/j.msard.2020.102326 -
Transcript-specific regulation in T-cells in multiple sclerosis susceptibility
Lies Van Horebeek, An Goris
European Journal of Human Genetics - Peer reviewed - Access status: Gold - DOI: 10.1038/s41431-020-0615-y -
Smoking and multiple sclerosis risk: a Mendelian randomization study
Marijne Vandebergh, An Goris
Journal of Neurology - Peer reviewed - Access status: Gold - DOI: 10.1007/s00415-020-09980-4 -
Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients
Ide Smets, An Goris, Marijne Vandebergh, Jelle Demeestere, Stefan Sunaert, Patrick Dupont, Bénédicte Dubois
Scientific Reports - Peer reviewed - Access status: Gold - DOI: 10.1038/s41598-021-81035-8 -
A pharmacogenetic study implicates NINJ2 in the response to Interferon-β in multiple sclerosis
Silvia Peroni, Melissa Sorosina, Sunny Malhotra, Ferdinando Clarelli, Ana Maria Osiceanu, Laura Ferrè, Tina Roostaei, Jordi Rio, Luciana Midaglia, Luisa María Villar, José Carlos Álvarez-Cermeño, Clara Guaschino, Marta Radaelli, Lorena Citterio, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Vittorio Martinelli, Xavier Montalban, Howard L Weiner, Philip de Jager, Giancarlo Comi, Federica Esposito, Manuel Comabella, Filippo Martinelli-Boneschi
Multiple Sclerosis Journal - Peer reviewed - Access status: No - DOI: 10.1177/1352458519851428 -
Finding cell-specific expression patterns in the early Ciona embryo with single-cell RNA-seq
Garth R. Ilsley, Ritsuko Suyama, Takeshi Noda, Nori Satoh, Nicholas M. Luscombe
Scientific Reports - Peer reviewed - Access status: Gold - DOI: 10.1038/s41598-020-61591-1 -
Ensembl 2021
Kevin L Howe, Premanand Achuthan, James Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Andrey G Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Mehrnaz Charkhchi, Carla Cummins, Luca Da Rin Fioretto, Claire Davidson, Kamalkumar Dodiya, Bilal El Houdaigui, Reham Fatima, Astrid Gall, Carlos Garcia Giron, Tiago Grego, Cristina Guijarro-Clarke, Leanne Haggerty, Anmol Hemrom, Thibaut Hourlier, Osagie G Izuogu, Thomas Juettemann, Vinay Kaikala, Mike Kay, Ilias Lavidas, Tuan Le, Diana Lemos, Jose Gonzalez Martinez, José Carlos Marugán, Thomas Maurel, Aoife C McMahon, Shamika Mohanan, Benjamin Moore, Matthieu Muffato, Denye N Oheh, Dimitrios Paraschas, Anne Parker, Andrew Parton, Irina Prosovetskaia, Manoj P Sakthivel, Ahamed I Abdul Salam, Bianca M Schmitt, Helen Schuilenburg, Dan Sheppard, Emily Steed, Michal Szpak, Marek Szuba, Kieron Taylor, Anja Thormann, Glen Threadgold, Brandon Walts, Andrea Winterbottom, Marc Chakiachvili, Ameya Chaubal, Nishadi De Silva, Bethany Flint, Adam Frankish, Sarah E Hunt, Garth R IIsley, Nick Langridge, Jane E Loveland, Fergal J Martin, Jonathan M Mudge, Joanella Morales, Emily Perry, Magali Ruffier, John Tate, David Thybert, Stephen J Trevanion, Fiona Cunningham, Andrew D Yates, Daniel R Zerbino, Paul Flicek
Nucleic Acids Research - Peer reviewed - Access status: Gold - DOI: 10.1093/nar/gkaa942 - Read more...
Genetic determinants of the humoral immune response in MS
Christiane Gasperi, Till F.M. Andlauer, Ana Keating, Benjamin Knier, Ana Klein, Verena Pernpeintner, Peter Lichtner, Ralf Gold, Frauke Zipp, Florian Then Bergh, Martin Stangel, Hayrettin Tumani, Brigitte Wildemann, Heinz Wiendl, Antonios Bayas, Tania Kümpfel, Uwe K. Zettl, Ralf A. Linker, Ulf Ziemann, Matthias Knop, Clemens Warnke, Manuel A. Friese, Friedemann Paul, Björn Tackenberg, Achim Berthele, Bernhard Hemmer
Neurology - Neuroimmunology Neuroinflammation - Peer reviewed - Access status: Gold - DOI: 10.1212/nxi.0000000000000827 -
Inflammation-related plasma and CSF biomarkers for multiple sclerosis
Jesse Huang, Mohsen Khademi, Lars Fugger, Örjan Lindhe, Lenka Novakova, Markus Axelsson, Clas Malmeström, Clara Constantinescu, Jan Lycke, Fredrik Piehl, Tomas Olsson, Ingrid Kockum
Proceedings of the National Academy of Sciences - Peer reviewed - Access status: Gold - DOI: 10.1073/pnas.1912839117 -
Epstein–Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis
M. Biström, D. Jons, E. Engdahl, R. Gustafsson, J. Huang, N. Brenner, J. Butt, L. Alonso‐Magdalena, M. Gunnarsson, M. Vrethem, N. Bender, T. Waterboer, G. Granåsen, T. Olsson, I. Kockum, O. Andersen, A. Fogdell‐Hahn, Peter Sundström
European Journal of Neurology - Peer reviewed - Access status: Gold - DOI: 10.1111/ene.14597 -
Pregnancy does not modify the risk of MS in genetically susceptible women
Cameron J. Adams, Sean L. Wu, Xiaorong Shao, Patrick T. Bradshaw, Edlin Gonzales, Jessica B. Smith, Anny H. Xiang, Kalliope H. Bellesis, Terrence Chinn, Steffan D. Bos, Marte Wendel-Haga, Tomas Olsson, Ingrid Kockum, Annette M. Langer-Gould, Catherine Schaefer, Lars Alfredsson, Lisa F. Barcellos
Neurology - Neuroimmunology Neuroinflammation - Peer reviewed - Access status: Gold - DOI: 10.1212/nxi.0000000000000898 -
Smoking and Epstein–Barr virus infection in multiple sclerosis development
Anna Karin Hedström, Jesse Huang, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Scientific Reports - Peer reviewed - Access status: Gold - DOI: 10.1038/s41598-020-67883-w -
GeneSetCluster: a tool for summarizing and integrating gene-set analysis results
Ewoud Ewing, Nuria Planell-Picola, Maja Jagodic, David Gomez-Cabrero
BMC Bioinformatics - Peer reviewed - Access status: Gold - DOI: 10.1186/s12859-020-03784-z -
Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)
Sonja Hochmeister, Shahin Aeinehband, Charles Dorris, Rasmus Berglund, Michaela T. Haindl, Vid Velikic, Sven A. Gustafsson, Tomas Olsson, Fredrik Piehl, Maja Jagodic, Manuel Zeitelhofer, Milena Z. Adzemovic
Frontiers in Neurology - Peer reviewed - Access status: Gold - DOI: 10.3389/fneur.2020.600401 -
Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
Karl E. Carlström, Keying Zhu, Ewoud Ewing, Inge E. Krabbendam, Robert A. Harris, Ana Mendanha Falcão, Maja Jagodic, Gonçalo Castelo-Branco, Fredrik Piehl
Nature Communications - Peer reviewed - Access status: Gold - DOI: 10.1038/s41467-020-17871-5 -
Epigenetic insights into multiple sclerosis disease progression
L. Kular, M. Jagodic
Journal of Internal Medicine - Peer reviewed - Access status: Gold - DOI: 10.1111/joim.13045 -
Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking
Mikael V Ringh, Michael Hagemann-Jensen, Maria Needhamsen, Susanna Kullberg, Jan Wahlström, Johan Grunewald, Boel Brynedal, Maja Jagodic, Tomas J Ekström, Johan Öckinger, Lara Kular
Multiple Sclerosis Journal - Peer reviewed - Access status: Gold - DOI: 10.1177/1352458520943768 -
Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis
Gabriel Mangeat, Russell Ouellette, Maxime Wabartha, Benjamin De Leener, Michael Plattén, Virginija Danylaité Karrenbauer, Marcel Warntjes, Nikola Stikov, Caterina Mainero, Julien Cohen‐Adad, Tobias Granberg
Journal of Neuroimaging - Peer reviewed - Access status: Gold - DOI: 10.1111/jon.12725 -
7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis
Russell Ouellette, Constantina A Treaba, Tobias Granberg, Elena Herranz, Valeria Barletta, Ambica Mehndiratta, Benjamin De Leener, Shahamat Tauhid, Fawad Yousuf, Sarah M Dupont, Eric C Klawiter, Jacob A Sloane, Rohit Bakshi, Julien Cohen-Adad, Caterina Mainero
Brain - Peer reviewed - Access status: Gold - DOI: 10.1093/brain/awaa249 -
C-type lectin receptors Mcl and Mincle control development of multiple sclerosis–like neuroinflammation
Marie N’diaye, Susanna Brauner, Sevasti Flytzani, Lara Kular, Andreas Warnecke, Milena Z. Adzemovic, Eliane Piket, Jin-Hong Min, Will Edwards, Filia Mela, Hoi Ying Choi, Vera Magg, Tojo James, Magdalena Linden, Holger M. Reichardt, Michael R. Daws, Jack van Horssen, Ingrid Kockum, Robert A. Harris, Tomas Olsson, Andre O. Guerreiro-Cacais, Maja Jagodic
Journal of Clinical Investigation - Peer reviewed - Access status: Gold - DOI: 10.1172/jci125857 -
Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression
Diana M. Ciuculete, Sarah Voisin, Lara Kular, Nipuni Welihinda, Jörgen Jonsson, Maja Jagodic, Jessica Mwinyi, Helgi B. Schiöth
Epigenetics - Peer reviewed - Access status: Gold - DOI: 10.1080/15592294.2019.1700628 -
Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis
Tobias Granberg, Thomas Moridi, Judith S. Brand, Susanne Neumann, Martin Hlavica, Fredrik Piehl, Benjamin V. Ineichen
Journal of Neurology - Peer reviewed - Access status: Gold - DOI: 10.1007/s00415-020-09971-5 -
Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort
Stefanos Klironomos, Antonios Tzortzakakis, Annika Kits, Claes Öhberg, Evangelia Kollia, Amir Ahoromazdae, Håkan Almqvist, Åsa Aspelin, Heather Martin, Russell Ouellette, Jonathan Al-Saadi, Mikael Hasselberg, Mansour Haghgou, Mitra Pedersen, Sven Petersson, Johannes Finnsson, Johan Lundberg, Anna Falk Delgado, Tobias Granberg
Radiology - Peer reviewed - Access status: Gold - DOI: 10.1148/radiol.2020202791 -
Neurological manifestations of coronavirus infections – a systematic review
Jesper Almqvist, Tobias Granberg, Antonios Tzortzakakis, Stefanos Klironomos, Evangelia Kollia, Claes Öhberg, Roland Martin, Fredrik Piehl, Russell Ouellette, Benjamin V. Ineichen
Annals of Clinical and Translational Neurology - Peer reviewed - Access status: Gold - DOI: 10.1002/acn3.51166 -
Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability
Anne Kerbrat, Charley Gros, Atef Badji, Elise Bannier, Francesca Galassi, Benoit Combès, Raphaël Chouteau, Pierre Labauge, Xavier Ayrignac, Clarisse Carra-Dalliere, Josefina Maranzano, Tobias Granberg, Russell Ouellette, Leszek Stawiarz, Jan Hillert, Jason Talbott, Yasuhiko Tachibana, Masaaki Hori, Kouhei Kamiya, Lydia Chougar, Jennifer Lefeuvre, Daniel S Reich, Govind Nair, Paola Valsasina, Maria A Rocca, Massimo Filippi, Renxin Chu, Rohit Bakshi, Virginie Callot, Jean Pelletier, Bertrand Audoin, Adil Maarouf, Nicolas Collongues, Jérôme De Seze, Gilles Edan, Julien Cohen-Adad
Brain - Peer reviewed - Access status: Gold - DOI: 10.1093/brain/awaa162 -
MRI‐Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis
Michael Platten, Juha Martola, Katharina Fink, Russell Ouellette, Fredrik Piehl, Tobias Granberg
Journal of Neuroimaging - Peer reviewed - Access status: No - DOI: 10.1111/jon.12676 -
Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients. . 2021 Oct;13(20):1607-1618. doi: /
Fernandes SJ, Ericsson M, Khademi M, Jagodic M, Olsson T, Gomez-Cabrero D, Kockum I, Tegnér J.
Epigenomics - Peer reviewed - Access status: Gold - DOI: 10.2217/epi-2021-0205 -
Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology
Zheleznyakova GY, Piket E, Needhamsen M, Hagemann-Jensen M, Ekman D, Han Y, James T, Khademi M, Al Nimer F, Scicluna P, Huang J, Kockum I, Faridani OR, Olsson T, Piehl F, Jagodic M
Proc Natl Acad Sci U S A. 2021 Apr 27;118(17) - Peer reviewed - Access status: Gold - DOI: 10.1073/pnas.2011574118 -
Cytomegalovirus seropositivity is associated with reduced risk of multiple sclerosis - a presymptomatic case-control study.
Grut V, Biström M, Salzer J, Stridh P, Jons D, Gustafsson R, Fogdell-Hahn A, Huang J, Brenner N, Butt J, Bender N, Lindam A, Alonso-Magdalena L, Gunnarsson M, Vrethem M, Bergström T, Andersen O, Kockum I, Waterboer T, Olsson T, Sundström P
Eur J Neurol. - Peer reviewed - Access status: Gold - DOI: 10.1111/ene.14961 -
Assessing the preanalytical variability of plasma and cerebrospinal fluid processing and its effects on inflammation-related protein biomarkers.
Huang J, Khademi M, Lindhe Ö, Jönsson G, Piehl F, Olsson T, Kockum I
Mol Cell Proteomics. - Peer reviewed - Access status: Gold - DOI: -
Seasonal variability of serum 25-hydroxyvitamin D on multiple sclerosis onset.
Stridh P, Kockum I, Huang J
Sci Rep - Peer reviewed - Access status: Gold - DOI: 10.1038/s41598-021-00344-0 -
Season of birth is associated with multiple sclerosis and disease severity
Stridh P, Huang J, Hedström AK, Alfredsson L, Olsson T, Hillert J, Manouchehrinia A, Kockum I
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL - Peer reviewed - Access status: Gold - DOI: 10.1177/20552173211065730 -
Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study
Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive P H, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg Z, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle Jfor the RDB in the Swiss Multiple Sclerosis Cohort Study Group
Lancet Neurology - Peer reviewed - Access status: No - DOI: 10.1016/s1474-4422(22)00009-6 -
Natural Killer Cells in Multiple Sclerosis: Entering the Stage
Beliën, Jarne; Goris, An; Matthys, Patrick
FRONTIERS IN IMMUNOLOGY - Peer reviewed - Access status: Gold - DOI: 10.3389/fimmu.2022.869447 -
Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.
Vandebergh, Marijne; Degryse, Nicolas; Dubois, Benedicte; Goris, An
JOURNAL OF NEUROLOGY - Peer reviewed - Access status: No - DOI: 10.1007/s00415-022-11072-4 -
Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study.
Vandebergh, Marijne; Becelaere, Sara; Dubois, Benedicte; Goris, An; CHARGE, Inflammation Working Grp
Frontiers In Immunology - Peer reviewed - Access status: Gold - DOI: 10.3389/fimmu.2022.834644 -
Human immune diversity: from evolution to modernity.
Liston, Adrian; Humblet-Baron, Stephanie; Duffy, Darragh; Goris, An
Nature Immunology - Peer reviewed - Access status: Gold - DOI: 10.1038/s41590-021-01058-1 -
Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis.
Vandebergh, Marijne; Andlauer, Till FM; Zhou, Yuan; Mallants, Klara; Held, Friederike; Aly, Lilian; Taylor, Bruce V; Hemmer, Bernhard; Dubois, Benedicte; Goris, An
Annals Of Neurology - Peer reviewed - Access status: Gold - DOI: 10.1002/ana.26061 -
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.
Patsopoulos, Nikolas A; Baranzini, Sergio E; Santaniello, Adams; Shoostari, Parisa; Cotsapas, Chris; Wong, Garrett; Beecham, Ashley H; James, Tojo; Replogle, Joseph; Vlachos, Ioannis S; McCabe, Cristin; Pers, Tune H; Brandes, Aaron; White, Charles; Keenan, Brendan; Cimpean, Maria; Winn, Phoebe; Panteliadis, Ioannis-Pavlos; Robbins, Allison; Andlauer, Till FM; Zarzycki, Onigiusz; Dubois, Benedicte; Goris, An; Sondergaard, Helle Bach; Sellebjerg, Finn; Sorensen, Per Soelberg; Ullum, Henrik; Thorner, Lise Wegner; Saarela, Janna; Cournu-Rebeix, Isabelle; Damotte, Vincent; Fontaine, Bertrand; Guillot-Noel, Lena; Lathrop, Mark; Vukusic, Sandra; Berthele, Achim; Pongratz, Viola; Gasperi, Christiane; Graetz, Christiane; Grummel, Verena; Hemmer, Bernhard; Hoshi, Muni; Knier, Benjamin; Korn, Thomas; Lill, Christina M; Luessi, Felix; Muehlau, Mark; Zipp, Frauke; Dardiotis, Efthimios; Agliardi, Cristina; Amoroso, Antonio; Barizzone, Nadia; Benedetti, Maria D; Bernardinelli, Luisa; Cavalla, Paola; Clarelli, Ferdinando; Comi, Giancarlo; Cusi, Daniele; Esposito, Federica; Ferre, Laura; Galimberti, Daniela; Guaschino, Clara; Leone, Maurizio A; Martinelli, Vittorio; Moiola, Lucia; Salvetti, Marco; Sorosina, Melissa; Vecchio, Domizia; Zauli, Andrea; Santoro, Silvia; Mancini, Nicasio; Zuccala, Miriam; Mescheriakova, Julia; van Duijn, Cornelia; Bos, Steffan D; Celius, Elisabeth G; Spurkland, Anne; Comabella, Manuel; Montalban, Xavier; Alfredsson, Lars; Bomfim, Izaura L; Gomez-Cabrero, David; Hillert, Jan; Jagodic, Maja; Linden, Magdalena; Piehl, Fredrik; Jelcic, Ilijas; Martin, Roland; Sospedra, Mirela; Baker, Amie; Ban, Maria; Hawkins, Clive; Hysi, Pirro; Kalra, Seema; Karpe, Fredrik; Khadake, Jyoti; Lachance, Genevieve; Molyneux, Paul; Neville, Matthew; Thorpe, John; Bradshaw, Elizabeth; Caillier, Stacy J; Calabresi, Peter; Cree, Bruce AC; Cross, Anne; Davis, Mary; de Bakker, Paul WI; Delgado, Silvia; Dembele, Marieme; Edwards, Keith; Fitzgerald, Kate; Frohlich, Irene Y; Gourraud, Pierre-Antoine; Haines, Jonathan L; Hakonarson, Hakon; Kimbrough, Dorlan; Isobe, Noriko; Konidari, Ioanna; Lathi, Ellen; Lee, Michelle H; Li, Taibo; An, David; Zimmer, Andrew; Madireddy, Lohith; Manrique, Clara P; Mitrovic, Mitja; Olah, Marta; Patrick, Ellis; Pericak-Vance, Margaret A; Piccio, Laura; Schaefer, Cathy; Weiner, Howard; Lage, Kasper; Scott, Rodney J; Lechner-Scott, Jeannette; Leal, Rod; Moscato, Pablo; Booth, David R; Stewart, Graeme J; Vucic, Stephen; Pame, Grant; BamettO, Michael; Mason, Deborah; GriffithS, Lyn; Broadley, Simon; Tajouri, Lotti; Baxter, Alan; Slee, Mark; Taylor, Bruce V; Charlesworth, Jac; Kilpatrick, Trevor J; Rubio, Justin; Jokubaitis, Vilija; Wiley, James; Butzkueven, Helmut; Leslie, Stephen; Motyer, Allan; Stankovich, Jim; Carroll, William M; Kermode, Allan G; Edrin, Marzena; Barclay, Murray; Peyrin-Biroulet, Laurent; Chamaillard, Mathias; Colombe, Jean-Frederick; Cottone, Mario; Croft, Anthony; D'Inca, Renata; Halfvarson, Jonas; Hanigan, Katherine; Henderson, Paul; Hugot, Jean-Pierre; Karban, Amir; Kennedy, Nicholas A; Khan, Mohammed Azam; Lemann, Marc; Levine, Arie; Massey, Dunecan; Milla, Monica; Motoey, Grant W; Ng, Sok Meng Evelyn; Oikonomnou, Joannis; Peeters, Harald; Proctor, Deborah D; Rahier, Jean-Francois; Roberts, Rebecca; Rutgeerts, Paul; Seibold, Frank; Stronati, Laura; Taylor, Kirstin M; Torkvist, Leif; Ublick, Kullak; Van Limbergen, Johan; Van Gossum, Andre; Vatn, Morten H; Zhang, Hu; Zhang, Wei; Donnelly, Peter; Barroso, Ines; Blackwe, Jenefer M; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden; Deloukas, Panos; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S; Mathew, Christopher G; Palmer, Colin NA; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J; Trembath, Richard C; Viswanathan, Ananth C; Wood, Nicholas W; Spencer, Chris CA; Band, Gavin; Bellenguez, Celine; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Pearson, Richard; Strange, Amy; Sul, Zhan; Vukcevic, Damj An; Langford, Cordelia; Hunt, Sarah E; Edkins, Sarah; Gwilliam, Rhian; Blackburn, Hannah; Bumpstead, Suzannah J; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; McCann, Owen T; Liddle, Jennifer; Potter, Simon C; Ravindrarajah, Radhi; Ricketts, Michelle; Waller, Matthew; Weston, Paul; Widaa, Sara; Whittaker, Pamela; Compston, Alastair; Hafler, David; Harbo, Hanne F; Hauser, Stephen L; Stewart, Graeme; D'Alfonso, Sandra; Hadjigeorgiou, Georgios; Taylor, Bruce; Barcellos, Lisa F; Booth, David; Hintzen, Rogier; Kockum, Ingrid; Martinelli-Boneschi, Filippo; McCauley, Jacob L; Oksenberg, Jorge R; Oturai, Annette; Sawcer, Stephen; Ivinson, Adrian J; Olsson, Tomas; De Jager, Philip L
Science - Peer reviewed - Access status: Gold - DOI: 10.1126/science.aav7188 -
Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients
Held F, Kalluri SR, Berthele A, Klein AK, Reindl M, Hemmer B
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL - Peer reviewed - Access status: Gold - DOI: 10.1177/20552173211022767 -
The Aryl Hydrocarbon Receptor-Dependent TGF-alpha/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis
Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V
Neurol Neuroimmunol Neuroinflamm - Peer reviewed - Access status: Gold - DOI: 10.1212/nxi.0000000000001043 -
Systematic Assessment of Medical Diagnoses Preceding the First Diagnosis of Multiple Sclerosis
Gasperi C, Hapfelmeier A, Daltrozzo T, Schneider A, Donnachie E, Hemmer B.
NEUROLOGY - Peer reviewed - Access status: No - DOI: 10.1212/wnl.0000000000012074 -
Trends in the environmental risk assessment for the early onset of multiple sclerosis
Huang J, Kockum I, Stridh P
Mult Scler Relat Disord. - Peer reviewed - Access status: Green - DOI: 10.1016/j.msard.2022.104250 - Read more...
Association between exposure to combustion-related air pollution and multiple sclerosis risk
Hedström AK, Segersson D, Hillert J, Stridh P, Kockum I, Olsson T, Bellander T, Alfredsson L.
Int J Epidemiol - Peer reviewed - Access status: Green - DOI: 10.1212/nxi.0000000000200056 - Read more...
Overview of genotyping technologies and methods
Kockum I, Huang J, Stridh P
Curr Protoc - Peer reviewed - Access status: Green - DOI: 10.1002/cpz1.727 - Read more...
Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis.
Lauerer M, McGinnis J, Bussas M, El Husseini M, Pongratz V, Engl C, Wuschek A, Berthele A, Riederer I, Kirschke JS, Zimmer C, Hemmer B, Mühlau M.
J Neurol Neurosurg Psychiatry - Peer reviewed - Access status: Green - DOI: - Read more...
Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume
Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
Ann Clin Transl Neurol - Peer reviewed - Access status: Green - DOI: - Read more...
Association between brain volume and disability over time in multiple sclerosis
Moridi T, Stawiarz L, McKay KA, Ineichen BV, Ouellette R, Ferreira D, Muehlboeck JS, Westman E, Kockum I, Olsson T, Piehl F, Hillert J, Manouchehrinia A, Granberg T.
Mult Scler J Exp Transl Clin - Peer reviewed - Access status: Green - DOI: 10.1177/20552173221144230 - Read more...
Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis.
Starvaggi Cucuzza C, Longinetti E, Ruffin N, Evertsson B, Kockum I, Jagodic M, Al Nimer F, Frisell T, Piehl F.
Neurol Neuroimmunol Neuroinflamm. - Peer reviewed - Access status: Green - DOI: - Read more...
Lesion location across diagnostic regions in multiple sclerosis
Viola Pongratz, Matthias Bussas, Paul Schmidt, Sophia Grahl, Christiane Gasperi, Malek El Husseini, Laura Harabacz, Viktor Pineker, Dominik Sepp, Lioba Grundl, Benedikt Wiestler, Jan Kirschke, Claus Zimmer, Achim Berthele, Bernhard Hemmer, Mark Mühlau
Neuroimage Clin. - Peer reviewed - Access status: Green - DOI: - Read more...
A Scoping Review on Body Fluid Biomarkers for Prognosis and Disease Activity in Patients with Multiple Sclerosis.
Barizzone N, Leone M, Pizzino A, Kockum I; MultipleMS Consortium; Martinelli-Boneschi F, D'Alfonso S.
J Pers Med. - Peer reviewed - Access status: Green - DOI: 10.3390/jpm12091430 - Read more...
Locus for severity implicates CNS resilience in progression of multiple sclerosis
International Multiple Sclerosis Genetics Consortium, MultipleMS Consortium, , Adil Harroud, Pernilla Stridh, Jacob L. McCauley, Janna Saarela, Ingileif Jónsdóttir, Aletta M. R. van den Bosch, Hendrik J. Engelenburg, Ashley H. Beecham, Lars Alfredsson, Katayoun Alikhani, Lilyana Amezcua, Till F. M. Andlauer, Maria Ban, Lisa F. Barcellos, Nadia Barizzone, Tone Berge, Achim Berthele, Stefan Bittner, Yolanda Blanco, Steffan D. Bos, Farren B. S. Briggs, Stacy J. Caillier, Peter A. Calabresi, Domenico Caputo, David X. Carmona-Burgos, Paola Cavalla, Elisabeth G. Celius, Gabriel Cerono, Angel R. Chinea, Tanuja Chitnis, Ferdinando Clarelli, Manuel Comabella, Giancarlo Comi, Chris Cotsapas, Bruce C. A. Cree, Sandra D’Alfonso, Efthimios Dardiotis, Philip L. De Jager, Silvia R. Delgado, Bénédicte Dubois, Sinah Engel, Federica Esposito, Marzena J. Fabis-Pedrini, Massimo Filippi, Kathryn C. Fitzgerald, Christiane Gasperi, Lissette Gomez, Refujia Gomez, Georgios Hadjigeorgiou, Jörg Hamann, Friederike Held, Roland G. Henry, Jan Hillert, Jesse Huang, Inge Huitinga, Talat Islam, Noriko Isobe, Maja Jagodic, Allan G. Kermode, Michael Khalil, Trevor J. Kilpatrick, Ioanna Konidari, Karim L. Kreft, Jeannette Lechner-Scott, Maurizio Leone, Sara Llufriu, Felix Luessi, Lohith Madireddy, Sunny Malhotra, Ali Manouchehrinia, Clara P. Manrique, Filippo Martinelli-Boneschi, Andrea C. Martinez, Viviana Martinez-Maldonado, Elisabetta Mascia, Luanne M. Metz, Luciana Midaglia, Xavier Montalban, Jorge R. Oksenberg, Tomas Olsson, Annette Oturai, Kimmo Pääkkönen, Grant P. Parnell, Nikolaos A. Patsopoulos, Margaret A. Pericak-Vance, Fredrik Piehl, Justin P. Rubio, Albert Saiz, Adam Santaniello, Silvia Santoro, Catherine Schaefer, Finn Sellebjerg, Hengameh Shams, Klementy Shchetynsky, Claudia Silva, Vasileios Siokas, Helle B. Søndergaard, Melissa Sorosina, Bruce Taylor, Marijne Vandebergh, Elena S. Vasileiou, Domizia Vecchio, Pablo Villoslada, Margarete M. Voortman, Howard L. Weiner, Dennis Wever, V. Wee Yong, Kári Stefánsson, David A. Hafler, Graeme J. Stewart, Alastair Compston, Frauke Zipp, Hanne F. Harbo, Bernhard Hemmer, An Goris, Joost Smolders, Stephen L. Hauser, Ingrid Kockum, Stephen J. Sawcer, Sergio E. Baranzini.
Nature - Peer reviewed - Access status: Gold - DOI: 10.1038/s41586-023-06250-x - Read more...
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis
Thomas O G, Bronge M, Tengvall K, Akpinar B, Nilsson OB, Holmgren E, Hessa T, Gafvelin G, Khademi M, Alfredsson L, Martin R, Ortlieb Guerreiro-Cacais A, Grönlund H, Olsson T, Kockum I
Sci Adv. - Peer reviewed - Access status: Green - DOI: 10.1126/sciadv.adg3032 - Read more...
A genetic risk variant for multiple sclerosis severity is associated with brain atrophy
Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, Cuici; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid; Hemmer, Bernhard; Mühlau, Mark
Ann Neurol - Peer reviewed - Access status: Green - DOI: 10.1002/ana.26807 - Read more...
LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics
Giulio Ruffini ,Giada Damiani,Diego Lozano-Soldevilla,Nikolas Deco,Fernando E. Rosas,Narsis A. Kiani,Adrián Ponce-Alvarez,Morten L. Kringelbach,Robin Carhart-Harris,Gustavo Deco
PLoS Comput Biol - Peer reviewed - Access status: Green - DOI: 10.1371/journal.pcbi.1010811 - Read more...
LIBRA: an adaptative integrative tool for paired single-cell multi-omics data
Xabier Martinez-de-Morentin , Sumeer A. Khan , Robert Lehmann , Sisi Qu , Alberto Maillo , Narsis A. Kiani , Felipe Prosper , Jesper Tegner , David Gomez-Cabrero
Quant. Biol - Peer reviewed - Access status: Green - DOI: 10.15302/j-qb-022-0318 - Read more...
Supervised Learning Using Homology Stable Rank Kernels
Jens Agerberg, Ryan Ramanujam, Martina Scolamiero, Wojciech Chachólski
Front. Appl. Math. Stat. Sec. Mathematics of Computation and Data Science - Peer reviewed - Access status: Green - DOI: 10.3389/fams.2021.668046 - Read more...
Decomposing filtered chain complexes: Geometry behind barcoding algorithms
Wojciech Chachólski, Barbara Giunti, Alvin Jin, Claudia Landi
Computational Geometry - Peer reviewed - Access status: Green - DOI: 10.1016/j.comgeo.2022.101938 -
A topological data analysis based classification method for multiple measurements.
Henri Riihimäki, Wojciech Chachólski, Jakob Theorell, Jan Hillert, Ryan Ramanujam
BMC Bioinformatics - Peer reviewed - Access status: Green - DOI: 10.1186/s12859-020-03659-3 - Read more...
MultipleMS is funded by the European Union under the Horizon 2020 programme, grant agreement 733161. The contents of this website are the sole responsibility of the MultipleMS project and do not necessarily reflect the views of the European Union.
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